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Although the Supernatural DVD was filmed in Los Angeles, the principal shooting will take place in Vancouver, British Columbia. Thus, instead of shooting takes place normally in the region. "Dead in the Water" was shot in Buntzen Lake and the final scenes of "Simon Says" was filmed in Cleveland Dam. Other locations used in the show often reused two or three times, with the authority of art, with modifications to hide it. Heritage Park in Burnaby was used as a graveyard of "Red Sky at Morning," and from the location of the cottage gingerbread house "How I Met Your Mother DVD." In addition, Riverview Hospital, Coquitlam has served many functions for the series, including an application for "asylum" in a hospital of "In My Time of Dying", and a prison of "Folsom Prison Blues." Because the episodes usually take place in the middle of nowhere, filming often takes place in an old military base.

After being closed for years, buildings have been removed so that the roads that this set is mounted, such scenes crossroads.

Rather than having the series debut on Lost DVD , instead WB pilot episode made available for online distribution through Yahoo! one week before it premiered on the network as part of a promotion. After the transition to the CW Supernatural episodes were added to iTunes Store from Apple in December 2006, is one of the first CW series must be made available for sale online. The following month, the network began streaming episodes of the series on its Web site with limited commercial interruption, available for up to four weeks after the Sons of Anarchy DVD. Starting January 11, 2007, Network Ten in Australia has also begun to offer full episodes for download via their website, through an agreement with Warner Bros. Television. To fight against piracy, Ti began the first second season, five days before the original broadcast in the country, making the first major network Supernatural show available for free download in Australia prior to their release.

The following Bones DVD are available online just hours after being released. At the same time, incidents were also made available for download on Microsoft's Xbox Live Marketplace.